Synovial Sarcoma - Online Patient Support Group

Study of Selinexor and Doxorubicin

A new trial in Canada, not yet recruiting, will be testing the combination of Selinexor and Doxorubicin for advanced soft tissue sarcoma:

Selinexor was tested in a phase 1B study on its own:

The study showed promise for dedifferentiated liposarcoma but did not work for the 4 synovial sarcoma patients who participated in it.
The preclinical activity of Selinexor was tested in various cells in the following study but not in synovial sarcoma:

Would a combination with Carfilzomib improve the efficiency of Selinexor?