OncoTherapy Science Inc


This is about the frizzle gene Synovialmom was talking about.

Here is an article about the coming trial:


Here is a link to the company website:


Here are the results of the study done on mice:


Here is a page listing the phase 1 trial, called SYNFRIZZ, set to start in November in 3 Cancer

Centers in France (Lyon, Paris, Bordeaux):



Where are trials with on Frizzle in the US? Any updates? The Paris trial is only for EU patients with proof of insurance from EU -- any ideas around this?


Unfortunately, the first phase will only be in France. Later on, phase 2 may open in the US but it will take probably a couple years before getting there... I was told foreigners could participate as long as they had a valid insurance. I don't know what kind of insurance that would be. French healthcare works through French Social Security in other words a public/government insurance unlike many of its neighbors so I am wondering how it makes it easier to be German than American for this. Who did you contact for the information you got? The trial was supposed to start in December but it doesn't look like it started yet...


Professor Jean-Yves Blay. ■■■■■■■■■■■■■■■■■■■■■■■■■■■■■■■■

I contacted him in November and sent my proof of insurance certificate. I did not hear anything back. I will follow up and see. Here is what he wrote: -- I am not sure it what I sent will work???

He wrote:

The trial will be open anytime soon, so theoretically that would be feasible.

The main logistic problem is actually the insurance certificate, because EU and FR laws indicate that the patient MUST have social security coverage in order to participate to a clinical trial. This is often the problem with patients from outside EU. Is there a way for your insurance to provide you with this certificate? Of course the cost of the trials are paid. The care outside the trial are at stake here

Kind regards



This is something you should discuss with your insurance. Do they cover you if you travel to Europe and something bad happens that requires medical attention while you are there? Does it make a difference whether you want to participate in a trial or not, knowing they do not have to pay for the trial but may have to pay for the consequences if something goes wrong? In theory, it would be advantageous for them to cover you while you are in France because honestly, care is much cheaper in France than in the US... But of course, if it's not clearly spelled on a paper before it happens, the insurance may try to find every reason not to pay... I think that's why Professor Blay is asking for a certificate that shows they would specifically cover treatments in Europe. I am wondering if the insurance does not cover Europe, then would it be possible to purchase an insurance that would?


Good idea... I will see what I can find on the supplimentary side


Early results from the trial can be found here: