Could Synovial sarcoma be caused by a mutated gene?


I had read somewhere, I just don't remember where that said something to that effect. I've been trying to find that information again. Can anyone help me?


Most synovial sarcoma patients have a mutation gene in their synovial sarcoma cells which is called the SYT-SSX fusion gene. Pieces of chromosomes 18 and X broke and reassembled the wrong way in what is called a translocation. A gene on chromosome 18 called SS18 fused with one of three closely related genes on the X chromosome, SSX1, SSX2, and rarely SSX4, resulting in a fusion protein in which a piece of SS18 was truncated and replaced with a piece of SSX. A recent article gives a potential explanation on how this fusion protein may be leading to cancer: