Do you know the name of the liposomal doxorubicin? Is it doxil or myocet? Doxil is less cardiotoxic than doxorubicin but it mostly concentrates in the skin. Efficiency may depend on location and characteristics of tumor. Myocet is also less cardiotoxic than doxorubicin. It is not yet approved in the US. A phase I trial was completed:
But there hasn't been a phase II trial yet as far as I can tell.
Vinorelbine was tried some years ago with overall response of 6%:
Recently, it was tried in combination with gemcitabine. Clinical benefits were found in 25% of patients with soft tissue sarcoma:
Dacarbazine is in a phase II trial for sarcoma:
It's been commonly used in combination with other drugs in the past.It's odd that it is only tried now on its own.
Many people are taking votrient nowadays because the drug was recently approved for sarcoma. You can find a lot of information about it in the discussions section of this website.
What about high dose ifosfamide?