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Olaratumab with Doxorubicin


#1

Has anybody been on the olaratumab trial?

The results of the phase Ib/II trial were presented at ASCO:

http://abstracts.asco.org/156/AbstView_156_147332.html

It's not clear whether they had any synovial sarcoma patient on the trial but the results look promising.

The next trial is phase 3 and is not recruiting yet but probably will start soon:

https://clinicaltrials.gov/ct2/show/NCT02451943


#2

The phase 3 trial started recruiting in 126 locations...


#3

Report from the CTOS meeting on this trial:

http://www.targetedonc.com/conference/ctos-2015/addition-of-olaratumab-to-doxorubicin-extends-survival-by-nearly-one-year-in-soft-tissue-sarcoma


#4

A phase 1 trial of olaratumab as monotherapy:


#5

Olaratumab is now getting a new name, Lartruvo and it looks like it will be made available very soon to European soft tissue sarcoma patients:
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2016/09/news_detail_002602.jsp&mid=WC0b01ac058004d5c1


#6

The FDA just granted accelerated approval to olaratumab which we should call lartruvo:
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm525878.htm
Has anybody tried this drug?


#7

More information about Olaraumab from Dr. Mark Agulnik can be found here:
http://www.targetedonc.com/case-based-peer-perspectives/soft-tissue-sarcoma/sts-agulnik-case-1/olaratumab-for-sts


#8

This is an option for me if I pick it.


#9

Dr. Brian Van Tine is discussing Olaratumab here:
http://www.targetedonc.com/case-based-peer-perspectives/soft-tissue-sarcoma/sts-vantine-case-1/overall-survival-with-olaratumab


#10

More details on Olaratumab in the following interview of several oncologists:


They certainly make it sound very promising. I still would like to hear the experience of synovial sarcoma patients…


#11

A few sarcoma experts explain how they decide which patient should get Olaratumab+Doxorubicin in this video:


#12

A few more interesting videos regarding Olaratumab:




#13

I started Olaratumab (Lartruvo) in the beginning of March. My side effects have been next to nothing. I am tired and get a slight headache on days 3 and 4 of my chemo cycles. I have been taking Doxorubicin, but have almost reached my limit. I will have my scans on May 2 to see if the Lartruvo has been helping. So far, I have been very happy with the Lartruvo.


#14

Thanks for sharing Misty!