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Has anyone heard of/been offered Axitinib?


#1

Hi everyone,

Today my oncologist offered me a place in a clinical trial called Axi-STS which uses a drug called Axitinib. I had bilateral thoracotomies with laser resection at the end of last year and my recent scan shows quite a lot of recurrence already.

I was wondering if anybody has had this drug and can tell me what side effects to expect?

Cheers


#2

Is it the following trial?

https://clinicaltrials.gov/ct2/show/NCT01140737

Apparently, the trial is only held in UK so it may be difficult to find other patients with SS on the trial...

Wikipedia has a page with a list of adverse effects for this drug:

http://en.wikipedia.org/wiki/List_of_adverse_effects_of_axitinib

Here are the results of the phase III trial for pancreatic cancer in Japan:

http://jjco.oxfordjournals.org/content/early/2015/02/03/jjco.hyv011.long

It won't tell you if it works for sarcoma but it discusses adverse effects...


#3

Yes, that’s it. I’ve been entered into the trial now. It is being used for 4 subtypes of STS including ours. It’s been described to me as the ‘second generation’ of pozapanib and they are hoping for it to either have a better or longer lasting effect. We will see.(I am being treated at a cancer centre by one of the leading sarcoma specialists in Europe, his name is Dr Mike Leahy)


#4

Good luck! I hope it does work. We are in need of new treatment options!