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Gemcitabine and Taxotere VS IFOS - 14 days high dose for metastises


#1

Just got done with another consultation with a doctor at University of Chicago.... he thinks that Gemcitabine and Taxotere has just as good of a chance as IFOS for 14 days -- just easier on the body. Anyone have some experience on this?


#2

From what I have read from studies Gemcitabine + Taxotere works best on leiomyosarcoma. And I have read that other histologies have shown less promising response. Ifosfomide on the other hand is considered to be a drug that Synovial Sarcoma is especially responsive too. Synovial seems to respond more than any other Sarcoma type to Ifosfomide. I have had response from standard dose IFOS, but have never done High dose IFOS. And Synovial sarcoma really seems to respond to High Dose Ifosfomide (http://www.ncbi.nlm.nih.gov/pubmed/8174046).

I might also try to take Palifosfomide through "compassionate use". Palifosfomide is a stabilized form of the active metabolite in IFOS. Basically a lot of the side effects and toxic effects of IFOS are a result of the none active metabolites in IFOS. Here is a really good article about about it. http://sarcomahelp.org/learning_center/palifosfamide.html. I am currently trying to take this drug. The company (ZIOPHARM) is willing to give it to me for free but it has to be approved by the FDA since it has not been approved for any type of Cancer yet.

While I wait to try and get on Palifosfomide, I'm going to try Gemcitabine and Taxotere by the way. So, I will be able to tell you more about that drug combo in the near future.


#3

Drake pretty much summarized it. Synovial sarcoma usually responds better to ifosfamide than to gemcitabine + taxotere. I know of some people who had this combo and sometimes experienced a few months stable disease. In theory, it is easier on the body, but I remember Charbonnel (a member who passed away last year) told me for him it was pretty hard. So it may depend on the person...


#4

Keep me posted! -- I appreciate the information

Drake said:

From what I have read from studies Gemcitabine + Taxotere works best on leiomyosarcoma. And I have read that other histologies have shown less promising response. Ifosfomide on the other hand is considered to be a drug that Synovial Sarcoma is especially responsive too. Synovial seems to respond more than any other Sarcoma type to Ifosfomide. I have had response from standard dose IFOS, but have never done High dose IFOS. And Synovial sarcoma really seems to respond to High Dose Ifosfomide (http://www.ncbi.nlm.nih.gov/pubmed/8174046).

I might also try to take Palifosfomide through "compassionate use". Palifosfomide is a stabilized form of the active metabolite in IFOS. Basically a lot of the side effects and toxic effects of IFOS are a result of the none active metabolites in IFOS. Here is a really good article about about it. http://sarcomahelp.org/learning_center/palifosfamide.html. I am currently trying to take this drug. The company (ZIOPHARM) is willing to give it to me for free but it has to be approved by the FDA since it has not been approved for any type of Cancer yet.

While I wait to try and get on Palifosfomide, I'm going to try Gemcitabine and Taxotere by the way. So, I will be able to tell you more about that drug combo in the near future.


#5


Yes... I don't want the easier, I want the better method. It is tough to figure this stuff out.


Elodie Espesset said:

Drake pretty much summarized it. Synovial sarcoma usually responds better to ifosfamide than to gemcitabine + taxotere. I know of some people who had this combo and sometimes experienced a few months stable disease. In theory, it is easier on the body, but I remember Charbonnel (a member who passed away last year) told me for him it was pretty hard. So it may depend on the person...