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Does anybody know of a MK-3475 (pembrolizumab) trial where you can have more than 3 previous treatments?


#1

Hi - I am trying to find a trial for MK-3475 where you can have more than 3 previous treatments. Is anyone on one? Thank you.


#2

Took a quick look at clinicaltrials.gov and couldn't find one :-(

But there is a similar drug from a different manufacturer that seems to have less stringent criteria:

https://clinicaltrials.gov/show/NCT01375842


#3

Actually, I don't see the exclusion in the following trial:

https://clinicaltrials.gov/ct2/show/NCT02054806

But is your daughter already 18?


#4

Hi Elodie - thanks for your feedback. Katie is 18. I called the PA and Maryland sites and they are not taking sarcomas for this trial now. I am awaiting feedback from the NJ location. The pediatric trial opening at CHOP where she is a patient is only open up to age 17. This drug seems promising and will give her a better quality of life. I hope to find somewhere she can get. All the best. Trish

Elodie Espesset said:

Actually, I don't see the exclusion in the following trial:

https://clinicaltrials.gov/ct2/show/NCT02054806

But is your daughter already 18?


#5

Here are a few trials for similar drugs:

https://clinicaltrials.gov/ct2/show/NCT01772004

https://clinicaltrials.gov/ct2/show/NCT01975831

https://clinicaltrials.gov/ct2/show/NCT01714739