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Could Synovial sarcoma be caused by a mutated gene?


#1

I had read somewhere, I just don't remember where that said something to that effect. I've been trying to find that information again. Can anyone help me?


#2

Most synovial sarcoma patients have a mutation gene in their synovial sarcoma cells which is called the SYT-SSX fusion gene. Pieces of chromosomes 18 and X broke and reassembled the wrong way in what is called a translocation. A gene on chromosome 18 called SS18 fused with one of three closely related genes on the X chromosome, SSX1, SSX2, and rarely SSX4, resulting in a fusion protein in which a piece of SS18 was truncated and replaced with a piece of SSX. A recent article gives a potential explanation on how this fusion protein may be leading to cancer:

http://www.ncbi.nlm.nih.gov/pubmed/23540691