I think the Bethesda trial is similar to the T-cell immunotherapy trial my husband participated in here in Seattle at the Seattle Cancer Care Alliance. The trial here is similar in nature, but less toxic -- chemo was less time, IL2 was less as was the interfuron. But the process does take time. My husband did the lukaphresis procedure before he started any of the traditional treatments as we knew he showed the market (NYESO) and the trial would be an option at some point. Prior to the trial we did doxi/ifos, Trabectadin, and then had to do radiation on the largest tumor in his lung as it was pressing upon his esophagus. There is a ton more to the story of what he has gone through, however, for the t-cell treatment itself, we saw mixed results. The tumor that had been radiated has show considerable shrinkage, and some of the smaller mets in the lungs have shrunk. Many of the others however have either stayed the same or have grown slightly in size. The doctors are trying to figure out why the treatment didn't respond as it was supposed to ( this is a clinical trial, and my husband was patient 1 on this particular study) and they are also trying to figure out why the radiated tumor responded so well. We will be discussing the next treatment which could include a t-cell booster coupled with radiation, but we are not sure yet. If we don't see a good result, then we'll probably go to votrient. I believe our doctor at SCCA, Seth Pollack, has openings for the trial and I would happy to ask if he is looking for others to participate. Let me know. And if you'd like to know more about our "journey" over the past year, please visit our blog at www.blackburn-us.com.